反应详情

Potassium carbonate (1.65 gm; 12 mmol) was added to a solution of 2-methoxy-5-nitro phenol (1.69 g; 10 mmol) and benzyl bromide (1.71 gm; 10 mmol) in acetone (60 ml). The reaction mixture was refluxed for 12 hours. The solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate (150 ml) and water (50 ml). The ethyl acetate layer was separated, washed with water (2×50 ml), dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.5 g of 1-Benzyloxy-2-methoxy-5-nitrobenzene (Yield=96.5%)

1. temperatureThe reaction mixture was refluxed for 12 hours
2. customThe solvent was removed under reduced pressure
3. customthe residue was partitioned between ethyl acetate (150 ml) and water (50 ml)
4. customThe ethyl acetate layer was separated
5. washwashed with water (2×50 ml)
6. dry with materialdried over anhydrous magnesium sulfate
7. customRemoval of the solvent under reduced pressure