HRID1999

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CCOP(=O)(CCCCn1cnc2c1c(=O)[nH]c(=O)n2C)OCC

HCID15382433

未命名化合物

HCID19689195

未命名化合物

PRODUCTS

生成物

结构：CCOP(=O)(CCCCn1c(=O)c2c(ncn2CCCCP(=O)(OCC)OCC)n(C)c1=O)OCC

HCID19689280

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 70 °C

PROCEDURE

实验过程

8 g (0.022 mol) of 7-(4-diethylphosphonobutyl)-3-methylxanthine (according to Example 24) were suspended in 100 ml of DMF, treated with 6.13 g (0.027 mol) of diethyl 4-chlorobutanephosphonate and 3.7 g (0.028 mol) of activated potassium carbonate and heated at 70° C. for 4 hours. The product was then filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was chromatographed on a silica gel column (eluent: ethyl acetate/methanol 10:1).

WORKUP

后处理

filtrationThe product was then filtered
concentrationthe filtrate was concentrated under reduced pressure
customthe oily residue which remained was chromatographed on a silica gel column (eluent: ethyl acetate/methanol 10:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c12104568b5442eda2e049aa7fbffb8a
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05728686
来源说明: uspto-grants-1998_03

反应 SMILES

[CH2:1]([O:3][P:4]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:21]2[C:20](=[O:22])[NH:19][C:18](=[O:23])[N:17]([CH3:24])[C:16]=2[N:15]=[CH:14]1)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].Cl[CH2:26][CH2:27][CH2:28][CH2:29][P:30]([O:35][CH2:36][CH3:37])(=[O:34])[O:31][CH2:32][CH3:33].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:7]([O:6][P:4]([CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:21]2[C:20](=[O:22])[N:19]([CH2:26][CH2:27][CH2:28][CH2:29][P:30](=[O:34])([O:35][CH2:36][CH3:37])[O:31][CH2:32][CH3:33])[C:18](=[O:23])[N:17]([CH3:24])[C:16]=2[N:15]=[CH:14]1)([O:3][CH2:1][CH3:2])=[O:5])[CH3:8]