(R)-(-)-2-Amino-1-propanol → HCID 121408979, compound

HRID 2002533Notes

Reaction equation

HRID 2002533 reaction equation
[CH3:1][C@H:2]([CH2:4][OH:5])[NH2:3].[CH3:6][O:7][CH2:8][C@H:9]([O:11][c:12]1[n:17][c:16]([N:18]2[CH2:23][CH2:22][CH:21]([c:24]3[c:33]([c:27]4[nH:26][cH:25]3)[c:31]([O:32]C)[cH:30][cH:29][n:28]4)[CH2:20][CH2:19]2)[cH:15][c:14](Cl)[n:13]1)[CH3:10]>>[CH3:6][O:7][CH2:8][C@H:9]([O:11][c:12]1[n:13][c:14]([C:15]([NH:3][C@@H:2]([CH2:4][OH:5])[CH3:1])=[O:32])n[c:16]([N:18]2[CH2:23][CH2:22][CH:21]([c:24]3[c:33]([c:27]4[nH:26][cH:25]3)[cH:31][cH:30][cH:29][n:28]4)[CH2:20][CH2:19]2)[n:17]1)[CH3:10]

Participants

7

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 121409575HCID 121409575, compound

Product 1

HCID 121408979HCID 121408979, compound

Reagents, catalysts & solvents 4

HCID 81531DiisopropylethylamineReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-ea5173085c354af081d7f546174f94f7
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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