Trifluoroacetic acid → Trifluoroacetic acid

HRID 20073Notes

Reaction equation

HRID 20073 reaction equation
[O-:1][N+:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[N:8]([CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[C:9](=[O:11])[NH:10][C:3]=12.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[NH:15]1[CH2:14][CH2:13][CH:12]([N:8]2[C:4]3[C:3](=[N+:2]([O-:1])[CH:7]=[CH:6][CH:5]=3)[NH:10][C:9]2=[O:11])[CH2:17][CH2:16]1.[C:27]([OH:29])([C:26]([F:31])([F:30])[F:25])=[O:28]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178452066HCID 178452066, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 178518622HCID 178518622, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(4-oxido-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (45 mg, 0.135 mmol) was dissolved in dichloromethane (10 mL) and trifluoroacetic acid (5 mL) was added at room temperature. After 3 h, the volatiles were removed in vacuo to give the title compound as its TFA salt. MS 235.2 (M+1).

Workup

  1. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-7b64a62b94384540899888cc3bda1e72
Source dataset
uspto-grants-2010_06
Patent number
US07745427B2

Reaction notes

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