反应详情

A solution of 4-amino-3-[(1-benzylpiperidin-4-yl)amino)pyridine (2.8 g, 9.9 mmol) and carbonyldiimidazole (3.0 g, 18.5 mmol) in tetrahydrofuran (100 mL) was refluxed overnight. The reaction was cooled, concentrated and partitioned between chloroform (500 mL) and saturated sodium carbonate (100 mL). The organic phase was dried over magnesium sulfate and concentrated to give the title compound (2.8 g). MS 209 (M+1).

1. temperatureThe reaction was cooled
2. concentrationconcentrated
3. custompartitioned between chloroform (500 mL) and saturated sodium carbonate (100 mL)
4. dry with materialThe organic phase was dried over magnesium sulfate
5. concentrationconcentrated