Water → tert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylate

HRID 2015796Notes

Reaction equation

HRID 2015796 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([N:14]([c:23]2[c:28]([Cl:29])[cH:27][cH:26][cH:25][n:24]2)[C:15]([c:17]3[cH:22][cH:21][c:20](Br)[cH:19][cH:18]3)=[O:16])[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[cH:30]1[cH:38][n:37]([c:33]2[n:32][cH:31]1)[n:36][cH:35][cH:34]2.O>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:12]([N:14]([c:23]2[c:28]([Cl:29])[cH:27][cH:26][cH:25][n:24]2)[C:15]([c:17]3[cH:22][cH:21][c:20]([c:34]4[c:33]([n:37]5[n:36][cH:35]4)[n:32][cH:31][cH:30][cH:38]5)[cH:19][cH:18]3)=[O:16])[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]

Participants

8

Reactant 3

HCID 962WaterHCID 11636795Pyrazolo(1,5-a)pyrimidineHCID 117652956(R)-tert-butyl 3-(4-bromo-N-(3-chloropyridin-2-yl)benzamido)piperidine-1-carboxylate

Product 1

HCID 118898588tert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylate

Reagents, catalysts & solvents 4

HCID 517044Potassium AcetateReagentHCID 178479583HCID 178479583, compoundCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-03bd53927c3f4b248c57fd4c4304c1ce
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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