1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 178481807, compound

HRID 2016099Notes

Reaction equation

HRID 2016099 reaction equation

[CH3:1][n:2]1[c:6](B2OC(C)(C)C(C)(C)O2)[cH:5][cH:4][n:3]1.Br[c:7]1[n:11]([CH2:12][c:13]2[cH:18][cH:17][cH:16][cH:15][cH:14]2)[n:10][n:9][n:8]1>>[CH3:1][n:2]1[c:6]([c:7]2[n:11]([CH2:12][c:13]3[cH:18][cH:17][cH:16][cH:15][cH:14]3)[n:10][n:9][n:8]2)[cH:5][cH:4][n:3]1

Participants

8

Reactant 2

HCID 49129081-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

HCID 109775211-benzyl-5-bromo-1H-tetrazole

Product 1

HCID 178481807HCID 178481807, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 516892Sodium BicarbonateReagent

HCID 75537289[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneCatalyst

HCID 1140TolueneSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 80 °C

Sources & evidence

ORD record: ord-02fe111ca1d74299a0b185602aa28199
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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