Quinoline-3-boronic acid → HCID 178421590, compound

HRID 2016904Notes

Reaction equation

HRID 2016904 reaction equation
OB([c:1]1[cH:10][c:9]([c:4]2[n:3][cH:2]1)[cH:8][cH:7][cH:6][cH:5]2)O.[CH3:11][C@@:12]1([c:19]2[c:24]([OH:25])[n:23][c:22](Cl)[cH:21][cH:20]2)[C:17](=[O:18])[NH:16][CH2:15][CH2:14][CH2:13]1>>[CH3:11][C@@:12]1([c:19]2[c:24]([OH:25])[n:23][c:22]([c:1]3[cH:10][c:9]([c:4]4[n:3][cH:2]3)[cH:8][cH:7][cH:6][cH:5]4)[cH:21][cH:20]2)[C:17](=[O:18])[NH:16][CH2:15][CH2:14][CH2:13]1

Participants

9

Reactant 2

HCID 2734663Quinoline-3-boronic acidHCID 178421611HCID 178421611, compound

Product 1

HCID 178421590HCID 178421590, compound

Reagents, catalysts & solvents 6

HCID 962WaterReagentHCID 62657Potassium Phosphate, TribasicReagentHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylReagentHCID 10876480Bis(tri-o-tolylphosphine)palladium(II) DichlorideCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-7c864ddf3ba64da48346422d1c2226d3
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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