(R)-(+)-1-Boc-3-aminopyrrolidine → HCID 178452029, compound

HRID 2017710Notes

Reaction equation

HRID 2017710 reaction equation
Br[c:1]1[n:9][c:8]([c:4]2[cH:3][cH:2]1)[cH:7]c[cH:6][c:5]2[C:10]#[N:11].[CH3:12][C:13]([O:16][C:17]([N:19]1[CH2:24][C@H:22]([NH2:23])[CH2:21][CH2:20]1)=[O:18])([CH3:15])[CH3:14]>>[CH3:12][C:13]([O:16][C:17]([N:19]1[CH2:24][C@H:22]([NH:23][c:4]2[cH:10][n:11][c:1]([N:9]3[CH2:6][CH2:5]O[CH2:7][CH2:8]3)[cH:2][cH:3]2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])[CH3:14]

Participants

8

Reactant 2

HCID 854070(R)-(+)-1-Boc-3-aminopyrrolidineHCID 121410810HCID 121410810, compound

Product 1

HCID 178452029HCID 178452029, compound

Reagents, catalysts & solvents 5

HCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)ReagentHCID 167845palladium(II) acetateCatalystHCID 11618717Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphaneCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-390332c278bd4e0e9cb85e457ba5d4e3
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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