HCID 118863078, compound → HCID 118875380, compound

HRID 2017916Notes

Reaction equation

HRID 2017916 reaction equation

[CH3:1][c:2]1[c:10](B2OC(C)(C)C(C)(C)O2)[cH:9][c:7]([F:8])[c:4]([C:5]#[N:6])[cH:3]1.CC[O:11][C:12]([c:14]1[c:22](Br)[n:21]([c:16]2[n:15]1)[n:20][cH:19][cH:18][cH:17]2)=[O:13]>>[CH3:1][c:2]1[c:10]([c:22]2[n:21]([c:16]3[n:15][c:14]2[C:12]([OH:11])=[O:13])[n:20][cH:19][cH:18][cH:17]3)[cH:9][c:7]([F:8])[c:4]([C:5]#[N:6])[cH:3]1

Participants

8

Reactant 2

HCID 118863078HCID 118863078, compound

HCID 125469059HCID 125469059, compound

Product 1

HCID 118875380HCID 118875380, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 516892Sodium BicarbonateReagent

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)Catalyst

HCID 887MethanolSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 90 °C

Sources & evidence

ORD record: ord-23a31821601940f8b0f86c4b0bdd5996
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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