2-Amino-4-bromopyridine → 2-(2-Aminopyridin-4-yl)-4-chlorophenol

HRID 2017954Notes

Reaction equation

HRID 2017954 reaction equation
[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4](Br)[cH:3]1.OB([c:8]1[c:14]([OH:15])[cH:13][cH:12][c:10]([Cl:11])[cH:9]1)O>>[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4]([c:8]2[c:14]([OH:15])[cH:13][cH:12][c:10]([Cl:11])[cH:9]2)[cH:3]1

Participants

9

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 23005362(5-Chloro-2-hydroxyphenyl)boronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 1360636192-(2-Aminopyridin-4-yl)-4-chlorophenol

Reagents, catalysts & solvents 6

HCID 962WaterReagentHCID 14798Sodium HydroxideReagentHCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 887MethanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-3d2da69fc9e3469bbf468031b3df9aee
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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