2-Amino-4-bromopyridine → HCID 136387753, compound

HRID 2017974Notes

Reaction equation

HRID 2017974 reaction equation
OB([c:1]1[c:6]([OH:7])[cH:5][cH:4][c:3]([C:8]([F:11])([F:10])[F:9])[cH:2]1)O.[NH2:12][c:13]1[n:18][cH:17][cH:16][c:15](Br)[cH:14]1>>[NH2:12][c:13]1[n:18][cH:17][cH:16][c:15]([c:1]2[c:6]([OH:7])[cH:5][cH:4][c:3]([C:8]([F:11])([F:10])[F:9])[cH:2]2)[cH:14]1

Participants

9

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 59436609(2-Hydroxy-5-(trifluoromethyl)phenyl)boronic acid

Product 1

HCID 136387753HCID 136387753, compound

Reagents, catalysts & solvents 6

HCID 962WaterReagentHCID 14798Sodium HydroxideReagentHCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-5e0a6807176549a483225ca16e9046f4
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…