1-methyl-1H-pyrazol-4-amine → HCID 178480799, compound

HRID 2018032Notes

Reaction equation

HRID 2018032 reaction equation
[CH3:1][N:2]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C@H:3]1[CH2:6][C@H:5]([O:7][c:8]2[c:22]([c:12]3[n:11][c:10](Cl)[n:9]2)[c:15]([c:16]4[n:21][cH:20][cH:19][cH:18][cH:17]4)[cH:14][nH:13]3)[CH2:4]1.[CH3:30][n:31]1[n:36][cH:35][c:33]([NH2:34])[cH:32]1>>[CH3:1][N:2]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C@H:3]1[CH2:6][C@H:5]([O:7][c:8]2[c:22]([c:12]3[n:11][c:10]([NH:34][c:33]4[cH:32][n:31]([CH3:30])[n:36][cH:35]4)[n:9]2)[c:15]([c:16]5[n:21][cH:20][cH:19][cH:18][cH:17]5)[cH:14][nH:13]3)[CH2:4]1

Participants

8

Reactant 2

HCID 47709901-methyl-1H-pyrazol-4-amineHCID 178486066HCID 178486066, compound

Product 1

HCID 178480799HCID 178480799, compound

Reagents, catalysts & solvents 5

HCID 23683543Potassium t-amylateReagentHCID 167845palladium(II) acetateCatalystHCID 11618717Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphaneCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-2390c96b475141458d3d4b88f71a1bd6
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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