Bis(pinacolato)diborane → HCID 89816526, compound

HRID 2018121Notes

Reaction equation

HRID 2018121 reaction equation
CC1(C(C)(C)OB(B2OC(C)(C)C(C)(C)O2)O1)C.[CH3:1][N:2]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:3][c:4]1[c:9](Br)[cH:8][c:7]([S:10]([CH3:13])(=[O:12])=[O:11])[cH:6][cH:5]1.[CH3:21][O:22][C:23]([c:25]1[c:31]([C@H:32]([O:34][c:35]2[c:40]([NH2:41])[n:39][cH:38][c:37](Br)[cH:36]2)[CH3:33])[cH:30][c:28]([F:29])[cH:27][cH:26]1)=[O:24]>>[CH3:21][O:22][C:23]([c:25]1[c:31]([C@H:32]([O:34][c:35]2[c:40]([NH2:41])[n:39][cH:38][c:37]([c:9]3[c:4]([CH2:3][N:2]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH3:1])[cH:5][cH:6][c:7]([S:10]([CH3:13])(=[O:12])=[O:11])[cH:8]3)[cH:36]2)[CH3:33])[cH:30][c:28]([F:29])[cH:27][cH:26]1)=[O:24]

Participants

9

Reactant 3

HCID 2733548Bis(pinacolato)diboraneHCID 89807923HCID 89807923, compoundHCID 89808256Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro-, methyl ester

Product 1

HCID 89816526HCID 89816526, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 25953Cesium fluorideReagentHCID 75537289[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneCatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-51f9e5c048e24fc3a36c0c1c1ddf1c88
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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