Diboron tetrahydroxide → 1-Methyl-1H-benzoimidazole-6-boronic acid

HRID 2018283Notes

Reaction equation

HRID 2018283 reaction equation
[OH:1][B:2](B(O)O)[OH:3].[CH3:4][n:5]1[c:13]([c:8]2[n:7][cH:6]1)[cH:12][c:11](Br)[cH:10][cH:9]2>>[CH3:4][n:5]1[c:13]([c:8]2[n:7][cH:6]1)[cH:12][c:11]([B:2]([OH:3])[OH:1])[cH:10][cH:9]2

Participants

7

Reactant 2

HCID 10986154Diboron tetrahydroxideHCID 235376446-Bromo-1-methyl-1H-benzimidazole

Product 1

HCID 467386791-Methyl-1H-benzoimidazole-6-boronic acid

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 167845palladium(II) acetateCatalyst2×HCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-f9c9dd03a03f45768b903c07139e54b9
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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