Dimethylformamide → 4-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-ylamino]-piperidine-1-carboxylic acid isopropyl ester

HRID 201860Notes

Reaction equation

HRID 201860 reaction equation
[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH:10]([NH2:13])[CH2:11][CH2:12]1.[CH:34]([N:35]([CH:36]([CH3:37])[CH3:38])[CH2:39][CH3:40])([CH3:41])[CH3:42].[Cl:14][c:15]1[cH:16][c:17]([N:21]2[CH2:22][CH2:23][c:24]3[cH:25][c:26]([S:30](=[O:31])(=[O:32])[CH3:33])[cH:27][cH:28][c:29]32)[n:18][cH:19][n:20]1.[Cl:48][CH2:49][Cl:50].[O:43]=[CH:44][N:45]([CH3:46])[CH3:47]>>[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH:10]([NH:13][c:15]2[cH:16][c:17]([N:21]3[CH2:22][CH2:23][c:24]4[cH:25][c:26]([S:30](=[O:31])(=[O:32])[CH3:33])[cH:27][cH:28][c:29]43)[n:18][cH:19][n:20]2)[CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 46941577Isopropyl 4-aminopiperidine-1-carboxylateHCID 595665261-(6-Chloropyrimidin-4-yl)-5-(methylsulfonyl)indoline

Product 1

HCID 498487854-[6-(5-Methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-ylamino]-piperidine-1-carboxylic acid isopropyl ester

Sources & evidence

ORD record
ord-684857edad854c209ac6bbab7120df85
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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