Bis(pinacolato)diborane → HCID 178498021, compound

HRID 2018760Notes

Reaction equation

HRID 2018760 reaction equation
CC1(C(C)(C)OB(B2OC(C)(C)C(C)(C)O2)O1)C.[CH3:1][N:2]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:3][c:4]1[n:9]([CH3:10])[n:8][c:6]([CH3:7])[c:5]1Br.[CH3:18][O:19][C:20]([c:22]1[c:28]([CH:29]([O:31][c:32]2[c:37]([NH2:38])[n:36][cH:35][c:34](Br)[cH:33]2)[CH3:30])[cH:27][c:25]([F:26])[cH:24][cH:23]1)=[O:21]>>[CH3:18][O:19][C:20]([c:22]1[c:28]([CH:29]([O:31][c:32]2[c:37]([NH2:38])[n:36][cH:35][c:34]([c:5]3[c:4]([CH2:3][N:2]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH3:1])[n:9]([CH3:10])[n:8][c:6]3[CH3:7])[cH:33]2)[CH3:30])[cH:27][c:25]([F:26])[cH:24][cH:23]1)=[O:21]

Participants

8

Reactant 3

HCID 2733548Bis(pinacolato)diboraneHCID 89808256Benzoic acid, 2-[(1R)-1-[(2-amino-5-bromo-3-pyridinyl)oxy]ethyl]-4-fluoro-, methyl esterHCID 89816348HCID 89816348, compound

Product 1

HCID 178498021HCID 178498021, compound

Reagents, catalysts & solvents 4

HCID 962WaterReagentHCID 25953Cesium fluorideReagentHCID 887MethanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-b358032122df4c39bcf27e82ff0b9e01
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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