N-ethyltetrahydro-2H-pyran-4-amine → HCID 178463224, compound

HRID 2018823Notes

Reaction equation

HRID 2018823 reaction equation
[CH3:1][CH2:2][NH:3][CH:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1.[CH3:10][c:11]1[n:38][c:29]([O:30][CH2:31][c:32]2[cH:37][cH:36][cH:35][cH:34][cH:33]2)[c:15]([CH2:16][N:17]3[C:27](=[O:28])[c:26]([c:20]4[CH2:19][CH2:18]3)[c:24]([Cl:25])[c:23](OS(C(F)(F)F)(=O)=O)[cH:22][cH:21]4)[c:13]([CH3:14])[cH:12]1>>[CH3:1][CH2:2][N:3]([c:23]1[c:24]([Cl:25])[c:26]([c:20]2[cH:21][cH:22]1)[C:27](=[O:28])[N:17]([CH2:16][c:15]3[c:29]([O:30][CH2:31][c:32]4[cH:37][cH:36][cH:35][cH:34][cH:33]4)[n:38][c:11]([CH3:10])[cH:12][c:13]3[CH3:14])[CH2:18][CH2:19]2)[CH:4]5[CH2:9][CH2:8][O:7][CH2:6][CH2:5]5

Participants

7

Reactant 2

HCID 10964527N-ethyltetrahydro-2H-pyran-4-amineHCID 178425082HCID 178425082, compound

Product 1

HCID 178463224HCID 178463224, compound

Reagents, catalysts & solvents 4

HCID 10796Cesium carbonateReagentHCID 178420029HCID 178420029, compoundCatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-34212168edee4dc997721181692e8e28
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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