3,5-Dimethylpyrazole-4-boronic acid, pinacol ester → HCID 178434602, compound

HRID 2018878Notes

Reaction equation

HRID 2018878 reaction equation
[CH3:1][CH:2]([n:12]1[c:20]([c:15]2[cH:14][cH:13]1)[n:19][c:18](Cl)[cH:17][n:16]2)[c:3]3[c:10]([Cl:11])[c:8]([F:9])[cH:7][cH:6][c:4]3[Cl:5].[CH3:21][c:22]1[c:27](B2OC(C)(C)C(C)(C)O2)[c:25]([CH3:26])[nH:24][n:23]1>>[CH3:1][C@@H:2]([n:12]1[c:20]([c:15]2[cH:14][cH:13]1)[n:19][c:18]([c:27]3[c:25]([CH3:26])[nH:24][n:23][c:22]3[CH3:21])[cH:17][n:16]2)[c:3]4[c:10]([Cl:11])[c:8]([F:9])[cH:7][cH:6][c:4]4[Cl:5]

Participants

7

Reactant 2

HCID 162177133,5-Dimethylpyrazole-4-boronic acid, pinacol esterHCID 178461694HCID 178461694, compound

Product 1

HCID 178434602HCID 178434602, compound

Reagents, catalysts & solvents 4

HCID 25953Cesium fluorideReagentHCID 2734558Bis(tri-tert-butylphosphine)palladium(0)CatalystHCID 6228DimethylformamideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-0ce9ea4b708a41b58aaa2a9a85562e47
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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