4-(Hydroxymethyl)benzeneboronic acid → HCID 178485593, compound

HRID 2018883Notes

Reaction equation

HRID 2018883 reaction equation
[CH3:1][NH:2][C:3]([c:5]1[c:13]([c:8]2[nH:7][n:6]1)[cH:12][cH:11][c:10](Br)[cH:9]2)=[O:4].[OH:14][CH2:15][c:16]1[cH:21][cH:20][c:19](B(O)O)[cH:18][cH:17]1>>[CH3:1][NH:2][C:3]([c:5]1[c:13]([c:8]2[nH:7][n:6]1)[cH:12][cH:11][c:10]([c:19]3[cH:20][cH:21][c:16]([CH2:15][OH:14])[cH:17][cH:18]3)[cH:9]2)=[O:4]

Participants

7

Reactant 2

HCID 27347064-(Hydroxymethyl)benzeneboronic acidHCID 119086425HCID 119086425, compound

Product 1

HCID 178485593HCID 178485593, compound

Reagents, catalysts & solvents 4

HCID 25953Cesium fluorideReagentHCID 75537289[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneCatalystHCID 6228DimethylformamideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-364645d13952422da529877bb82e9a3a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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