2,3-Dichloropyridine → HCID 178496128, compound

HRID 2018886Notes

Reaction equation

HRID 2018886 reaction equation
[Cl:1][c:2]1[c:7](Cl)[n:6][cH:5][cH:4][cH:3]1.Clc1c(Br)nccc1.[CH3:8][O:9][CH2:10][CH2:11][O:12][c:13]1[cH:18][cH:17][c:16]([C:19]([NH:21][C@H:22]2[CH2:27][N:26]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:25][CH2:24][CH2:23]2)=[O:20])[cH:15][cH:14]1>>[CH3:8][O:9][CH2:10][CH2:11][O:12][c:13]1[cH:18][cH:17][c:16]([C:19]([N:21]([c:7]2[c:2]([Cl:1])[cH:3][cH:4][cH:5][n:6]2)[C@H:22]3[CH2:27][N:26]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:25][CH2:24][CH2:23]3)=[O:20])[cH:15][cH:14]1

Participants

7

Reactant 3

HCID 169882,3-DichloropyridineHCID 70163262-Bromo-3-chloropyridineHCID 178496130HCID 178496130, compound

Product 1

HCID 178496128HCID 178496128, compound

Reagents, catalysts & solvents 3

HCID 2724254Sodium bis(trimethylsilyl)amideReagentHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-dcd62ea9be6a4a4b900113dfa13e36a5
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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