反应详情

温度

70 °C

44.8 g (0.2 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of DMF, treated with 55 g (0.24 mol) of diethyl 4-chlorobutane-phosphonate and 50 g (0.32 mol) of activated potassium carbonate and heated at 70° C. for 4 hours and filtered, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate. filtered again and crystallized from diisopropyl ether.

1. filtrationfiltered
2. concentrationthe filtrate was concentrated under reduced pressure
3. filtrationfiltered again
4. customcrystallized from diisopropyl ether