1,4-Dimethyl-1H-1,2,3-triazole → 5-bromo-8-chloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one
Reaction equation
[CH3:1][c:2]1[n:7][n:6][n:4]([CH3:5])[cH:3]1.[Cl:8][c:9]1[c:20]([c:14]2[c:12]([Br:13])[cH:11][c:10]1I)[C:18](=[O:19])[NH:17][CH2:16][CH2:15]2>>[CH3:1][c:2]1[c:3]([c:10]2[c:9]([Cl:8])[c:20]([c:14]3[c:12]([Br:13])[cH:11]2)[C:18](=[O:19])[NH:17][CH2:16][CH2:15]3)[n:4]([CH3:5])[n:6][n:7]1Participants
8
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 110 °C
Sources & evidence
- ORD record
- ord-b36f84da92434c6e8ac56f68ce9705d7
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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