Methyl Acrylate → (E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate

HRID 2020147Notes

Reaction equation

HRID 2020147 reaction equation

[F:1][c:2]1[c:8]([CH:9]=[O:10])[c:6]([F:7])[cH:5][c:4](Br)[cH:3]1.[CH3:11][O:12][C:13]([CH:15]=[CH2:16])=[O:14]>>[CH3:11][O:12][C:13](\[CH:15]=[CH:16]\[c:4]1[cH:3][c:2]([F:1])[c:8]([CH:9]=[O:10])[c:6]([F:7])[cH:5]1)=[O:14]

Participants

7

Reactant 2

HCID 7294Methyl Acrylate

HCID 27732904-Bromo-2,6-difluorobenzaldehyde

Product 1

HCID 117719453(E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate

Reagents, catalysts & solvents 4

HCID 583616Cesium pivalateReagent

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)Catalyst

HCID 6342AcetonitrileSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 100 °C

Sources & evidence

ORD record: ord-bd12fcb8ad0e444bad32c95a8afb7078
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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