Methyl Acrylate → (E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate
Reaction equation
[CH3:1][O:2][C:3]([CH:5]=[CH2:6])=[O:4].[F:7][c:8]1[c:14]([CH:15]=[O:16])[c:12]([F:13])[cH:11][c:10](Br)[cH:9]1>>[CH3:1][O:2][C:3](\[CH:5]=[CH:6]\[c:10]1[cH:9][c:8]([F:7])[c:14]([CH:15]=[O:16])[c:12]([F:13])[cH:11]1)=[O:4]Participants
7
Reactant 2
Product 1
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 100 °C
Sources & evidence
- ORD record
- ord-408b2edf61bb4133b8299f965d4b2b8d
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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