Methyl Acrylate → (E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate

HRID 2020178Notes

Reaction equation

HRID 2020178 reaction equation

[CH3:1][O:2][C:3]([CH:5]=[CH2:6])=[O:4].[F:7][c:8]1[c:14]([CH:15]=[O:16])[c:12]([F:13])[cH:11][c:10](Br)[cH:9]1>>[CH3:1][O:2][C:3](\[CH:5]=[CH:6]\[c:10]1[cH:9][c:8]([F:7])[c:14]([CH:15]=[O:16])[c:12]([F:13])[cH:11]1)=[O:4]

Participants

7

Reactant 2

HCID 7294Methyl Acrylate

HCID 27732904-Bromo-2,6-difluorobenzaldehyde

Product 1

HCID 117719453(E)-methyl 3-(3,5-difluoro-4-formylphenyl)acrylate

Reagents, catalysts & solvents 4

HCID 516951Monobasic potassium phosphateReagent

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)Catalyst

HCID 1140TolueneSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 100 °C

Sources & evidence

ORD record: ord-ecc176fe66fc42a3979603323f23b589
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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