6-Bromoquinoline → HCID 178481932, compound

HRID 2022801Notes

Reaction equation

HRID 2022801 reaction equation

Br[c:1]1[cH:10][c:9]([c:4]2[cH:3][cH:2]1)[cH:8][cH:7][cH:6][n:5]2.[CH3:11][n:12]1[c:17](B2OC(C)(C)C(C)(C)O2)[cH:16][c:14]([NH2:15])[n:13]1>>[CH3:11][n:12]1[c:17]([c:1]2[cH:10][c:9]([c:4]3[cH:3][cH:2]2)[cH:8][cH:7][cH:6][n:5]3)[cH:16][c:14]([NH2:15])[n:13]1

Participants

8

Reactant 2

HCID 792436-Bromoquinoline

HCID 178481931HCID 178481931, compound

Product 1

HCID 178481932HCID 178481932, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 14798Sodium HydroxideReagent

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)Catalyst

HCID 8028TetrahydrofuranSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 80 °C

Sources & evidence

ORD record: ord-8e3326dd9a8f43d2b3fc690584ff6993
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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