6-Bromoquinoline → HCID 178517563, compound

HRID 2023183Notes

Reaction equation

HRID 2023183 reaction equation
Br[c:1]1[cH:10][c:9]([c:4]2[cH:3][cH:2]1)[cH:8][cH:7][cH:6][n:5]2.[O:11]=[C:12]1[c:31]([c:15]2[CH2:14][NH:13]1)[cH:30][cH:29][cH:28][c:16]2[O:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3>>[O:11]=[C:12]1[c:31]([c:15]2[CH2:14][NH:13]1)[cH:30][cH:29][cH:28][c:16]2[O:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]3[CH2:27][CH2:26][N:25]([c:1]4[cH:10][c:9]([c:4]5[cH:3][cH:2]4)[cH:8][cH:7][cH:6][n:5]5)[CH2:24][CH2:23]3

Participants

8

Reactant 2

HCID 792436-BromoquinolineHCID 178517564HCID 178517564, compound

Product 1

HCID 178517563HCID 178517563, compound

Reagents, catalysts & solvents 5

HCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)ReagentHCID 167845palladium(II) acetateCatalystHCID 469195262-(Di-tert-butylphosphanyl)-1-(2-methoxyphenyl)-1H-pyrroleCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-e6f198e5a4c145f1b6c36b0b782e5cde
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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