6-Bromoquinoline → HCID 178517563, compound

HRID 2023224Notes

Reaction equation

HRID 2023224 reaction equation
[O:1]=[C:2]1[c:21]([c:5]2[CH2:4][NH:3]1)[cH:20][cH:19][cH:18][c:6]2[O:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3.Br[c:22]1[cH:31][c:30]([c:25]2[cH:24][cH:23]1)[cH:29][cH:28][cH:27][n:26]2>>[O:1]=[C:2]1[c:21]([c:5]2[CH2:4][NH:3]1)[cH:20][cH:19][cH:18][c:6]2[O:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][N:15]([c:22]4[cH:31][c:30]([c:25]5[cH:24][cH:23]4)[cH:29][cH:28][cH:27][n:26]5)[CH2:14][CH2:13]3

Participants

8

Reactant 2

HCID 792436-BromoquinolineHCID 178517564HCID 178517564, compound

Product 1

HCID 178517563HCID 178517563, compound

Reagents, catalysts & solvents 5

HCID 4339838N'''-(1,1-Dimethylethyl)-N,N',N''-tris(tris(dimethylamino)phosphoranylidene)phosphorimidic triamideReagentHCID 167845palladium(II) acetateCatalystHCID 11547931BippyPhosCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-c9279db52e3c45fea39aa0ec25e27230
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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