反应详情

温度

70 °C

9 g (0.04 mol) of 7-methoxyethyl-3-methylxanthine were suspended in 100 ml of DMF, treated with 11 g (0.048 mol) of diethyl 4-chlorobutane-phosphonate and 10 g (0.064 mol) of activated potassium carbonate and heated at 70° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

1. filtrationThe solid was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. filtrationfiltered again
4. customcrystallized from diisopropyl ether