N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

HRID 2025578Notes

Reaction equation

HRID 2025578 reaction equation
[CH3:1][N:2]([S:11]([CH3:14])(=[O:13])=[O:12])[c:3]1[c:8]([CH2:9][NH2:10])[cH:7][cH:6][cH:5][cH:4]1.[Cl:15][c:16]1[n:30][c:29](Cl)[c:19]2[c:18]([n:22]([CH:23]3[O:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[n:21][cH:20]2)[cH:17]1>>[CH3:1][N:2]([S:11]([CH3:14])(=[O:13])=[O:12])[c:3]1[c:8]([CH2:9][NH:10][c:29]2[c:19]3[c:18]([n:22]([CH:23]4[O:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[n:21][cH:20]3)[cH:17][c:16]([Cl:15])[n:30]2)[cH:7][cH:6][cH:5][cH:4]1

Participants

6

Reactant 2

HCID 45480190N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 1254824194,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridine

Product 1

HCID 118512378N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

Reagents, catalysts & solvents 3

HCID 23672319Sodium trimethylsilanolateReagentHCID 6228DimethylformamideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-38f91cd547214dd89dd37f34f353eb18
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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