Tetrabutylammonium Cyanide → 4-Bromo-5-fluoro-2-methylbenzaldehyde

HRID 2026429Notes

Reaction equation

HRID 2026429 reaction equation
CCCC[N+](CCCC)(CCCC)CCCC.[C-]#N.[CH3:1][c:2]1[c:9]([CH:10]=[O:11])[cH:8][c:6]([F:7])[c:4]([Br:5])[cH:3]1>>[CH3:1][c:2]1[c:9]([CH:10]=[O:11])[cH:8][c:6]([F:7])[c:4]([Br:5])[cH:3]1

Participants

7

Reactant 2

HCID 165872Tetrabutylammonium CyanideHCID 121872174-Bromo-5-fluoro-2-methylbenzaldehyde

Product 1

HCID 121872174-Bromo-5-fluoro-2-methylbenzaldehyde

Reagents, catalysts & solvents 4

HCID 167845palladium(II) acetateCatalystHCID 178454858HCID 178454858, compoundCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-2fd198e9590b48d79e89d2ec604bb0e7
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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