Cesium fluoride → tert-butyl (3R)-3-[(4-bromo-3-fluorobenzoyl)(3-chloropyridin-2-yl)amino]piperidine-1-carboxylate
Reaction equation
[F-:1].[Cs+].[CH3:2][C:3]([O:6][C:7]([N:9]1[CH2:14][C@H:13]([N:15]([c:25]2[c:30]([Cl:31])[cH:29][cH:28][cH:27][n:26]2)[C:16]([c:18]3[cH:24][c:23](I)[c:21]([Br:22])[cH:20][cH:19]3)=[O:17])[CH2:12][CH2:11][CH2:10]1)=[O:8])([CH3:5])[CH3:4]>>[CH3:2][C:3]([O:6][C:7]([N:9]1[CH2:14][C@H:13]([N:15]([c:25]2[c:30]([Cl:31])[cH:29][cH:28][cH:27][n:26]2)[C:16]([c:18]3[cH:24][c:23]([F:1])[c:21]([Br:22])[cH:20][cH:19]3)=[O:17])[CH2:12][CH2:11][CH2:10]1)=[O:8])([CH3:5])[CH3:4]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 120 °C
Sources & evidence
- ORD record
- ord-f861cf05795f44da875bd8b716160e10
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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