Benzyl Bromide → 7-Benzyl-3-ethyl-3,7-dihydro-1H-purine-2,6-dione

HRID 2029Notes

Reaction equation

HRID 2029 reaction equation
[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][NH:8][C:7]=2[C:6](=[O:12])[NH:5][C:4]1=[O:13])[CH3:2].[CH2:14](Br)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>O>[CH2:14]([N:8]1[C:7]2[C:6](=[O:12])[NH:5][C:4](=[O:13])[N:3]([CH2:1][CH3:2])[C:11]=2[N:10]=[CH:9]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 3507373-ethylxanthine

Product 1

HCID 220073037-Benzyl-3-ethyl-3,7-dihydro-1H-purine-2,6-dione

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

18 g (0.1 mol) of 3-ethylxanthine were stirred at 60° C. for 2 hours with 19.2 g (0.11 mol) of benzyl bromide and 15.2 g (0.11 mol) of potassium carbonate. The reaction solution was transferred to an Edenmeyer flask and treated with 1000 ml of water. The precipitate was filtered off with suction, washed several times with warm water and dried at 50° C. under reduced pressure.

Workup

  1. filtrationThe precipitate was filtered off with suction
  2. washwashed several times with warm water
  3. customdried at 50° C. under reduced pressure

Sources & evidence

ORD record
ord-61cce6857443438ba8ad80c482010310
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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