Ammonia → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029012Notes

Reaction equation

HRID 2029012 reaction equation
[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C:8](=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH3:12].[Li+].CC(O[AlH-](OC(C)(C)C)OC(C)(C)C)(C)C>>[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C@H:8]([NH2:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 16688073Lithium aluminum-tri-tert-butoxyhydrideHCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 2

HCID 11026Titanium isopropoxideReagentHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-e47c40b3426348b2b900c2ed4f3e902f
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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