Benzylamine → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029021Notes

Reaction equation

HRID 2029021 reaction equation
[K+].CC(C([BH-](C(C(C)C)C)C(C(C)C)C)C)C.[NH2:1]Cc1ccccc1.[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C:9](=O)[CH2:8][CH2:7]1)(=[O:5])=[O:4]>>[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C@H:9]([NH2:1])[CH2:8][CH2:7]1)(=[O:5])=[O:4]

Participants

6

Reactant 3

HCID 7504BenzylamineHCID 23676661Potassium hydridotris(3-methylbutan-2-yl)borate(1-)HCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 2

HCID 11026Titanium isopropoxideReagentHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-597c3813a11e41a2af417fc4f54b1e4c
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…