Ammonia → (3R,4R)-4-Amino-1-(methylsulfonyl)piperidin-3-ol

HRID 2029048Notes

Reaction equation

HRID 2029048 reaction equation
[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C:8](=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH3:12].[Na+].CC(O[BH-](OC(C)=O)OC(C)=O)=O>>[CH3:1][S:2]([N:5]1[CH2:11][C@@H:9]([OH:10])[C@H:8]([NH2:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

6

Reactant 3

HCID 222AmmoniaHCID 23676153Sodium bis(acetyloxy)boranuidyl acetateHCID 178504951HCID 178504951, compound

Product 1

HCID 58777604(3R,4R)-4-Amino-1-(methylsulfonyl)piperidin-3-ol

Reagents, catalysts & solvents 2

HCID 11026Titanium isopropoxideReagentHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-ed1b326563f04280ab6095f760061960
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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