Benzylamine → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029058Notes

Reaction equation

HRID 2029058 reaction equation

[Na+].CC(O[BH-](OC(C)=O)OC(C)=O)=O.[NH2:1]Cc1ccccc1.[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C:9](=O)[CH2:8][CH2:7]1)(=[O:5])=[O:4]>>[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C@H:9]([NH2:1])[CH2:8][CH2:7]1)(=[O:5])=[O:4]

Participants

6

Reactant 3

HCID 7504Benzylamine

HCID 23676153Sodium bis(acetyloxy)boranuidyl acetate

HCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 2

HCID 11026Titanium isopropoxideReagent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 25 °C

Sources & evidence

ORD record: ord-0fd3c17ade9d49aebc9005b6cd9c7c65
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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