Tetrahydrofuran → 5-[[6-(2-cyclopropylpyrimidin-5-yl)-3,4-dihydro-1H-isoquinolin-2-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione

HRID 203079Notes

Reaction equation

HRID 203079 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:1][C:2]1([CH2:9][S:10](=[O:11])(=[O:12])[Cl:13])[NH:3][C:4](=[O:8])[NH:5][C:6]1=[O:7].[CH:14]1([c:17]2[n:18][cH:19][c:20](-[c:23]3[cH:24][c:25]4[c:30]([cH:31][cH:32]3)[CH2:29][NH:28][CH2:27][CH2:26]4)[cH:21][n:22]2)[CH2:15][CH2:16]1.[CH:33]([N:34]([CH2:35][CH3:36])[CH:37]([CH3:38])[CH3:39])([CH3:40])[CH3:41]>>[CH3:1][C:2]1([CH2:9][S:10](=[O:11])(=[O:12])[N:28]2[CH2:27][CH2:26][c:25]3[cH:24][c:23](-[c:20]4[cH:19][n:18][c:17]([CH:14]5[CH2:15][CH2:16]5)[n:22][cH:21]4)[cH:32][cH:31][c:30]3[CH2:29]2)[NH:3][C:4](=[O:8])[NH:5][C:6]1=[O:7]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 23133494674348-00-6HCID 667348536-[2-(Cyclopropyl)pyrimidin-5-yl]-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 694621805-[[6-(2-cyclopropylpyrimidin-5-yl)-3,4-dihydro-1H-isoquinolin-2-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione

Sources & evidence

ORD record
ord-f48549ed20974e05bcd776a0cd4265a4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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