3,5-Dibromo-4-methylpyridine → 5-Bromo-4-methylpyridine-3-carbonitrile

HRID 2031040Notes

Reaction equation

HRID 2031040 reaction equation
[OH-].CCC[CH2:1][N+:2](CCCC)(CCCC)CCCC.[CH3:3][c:4]1[c:10](Br)[cH:9][n:8][cH:7][c:5]1[Br:6]>>[CH3:3][c:4]1[c:10]([C:1]#[N:2])[cH:9][n:8][cH:7][c:5]1[Br:6]

Participants

6

Reactant 2

HCID 8193383,5-Dibromo-4-methylpyridineHCID 2723671Tetrabutylammonium Hydroxide

Product 1

HCID 70606815-Bromo-4-methylpyridine-3-carbonitrile

Reagents, catalysts & solvents 3

HCID 11714597Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)CatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-7ec6baf163374157adaafb90fec89e98
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…