Bromobenzene → 2-(benzylamino)-5-(3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-3-methylpyrimidin-4(3H)-one
Reaction equation
[Br:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][c:9]1[n:10][cH:11][c:12](-[c:17]2[cH:18][c:19]([F:24])[c:20]([OH:23])[cH:21][cH:22]2)[c:13](=[O:16])[n:14]1[CH3:15].[CH3:36][N:37]([c:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1)[CH3:44].[Cl:25][c:26]1[c:27]2[c:28]([n:29][cH:30][cH:31]1)[cH:32][c:33]([I:35])[s:34]2>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][c:9]1[n:10][cH:11][c:12](-[c:17]2[cH:18][c:19]([F:24])[c:20]([O:23][c:26]3[c:27]4[c:28]([n:29][cH:30][cH:31]3)[cH:32][c:33]([I:35])[s:34]4)[cH:21][cH:22]2)[c:13](=[O:16])[n:14]1[CH3:15]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-ee93bdc9478b418e91b10f4a6732a0a1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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