反应详情

To a solution of benzaldehyde (2 g; 18.9 mmol) and malononitrile (1.37 g; 20.7 mmol) in ethanol (40 ml) was added 5 drops of piperidine and the mixture was heated at reflux overnight. The reaction was cooled, evaporated then purified by flash column chromatography eluting with 1:9 ethyl acetate/hexane and the product containing fractions combined and evaporated to give 930 mg of 2-benzylidene-but-3-yne nitrile.

1. temperaturethe mixture was heated
2. temperatureat reflux overnight
3. temperatureThe reaction was cooled
4. customevaporated
5. customthen purified by flash column chromatography
6. washeluting with 1:9 ethyl acetate/hexane
7. additionthe product containing fractions
8. customevaporated