Selectfluor → HCID 178508376, compound

HRID 2032913Notes

Reaction equation

HRID 2032913 reaction equation
[NH2:1][c:2]1[n:7][cH:6][c:5]([c:8]2[c:16]([c:12]3[n:11][c:10]([N:23]4[C@@H:28]([CH2:29]O)[CH2:27][O:26][CH2:25][CH2:24]4)[n:9]2)[CH2:15][CH2:14][N:13]3[CH:17]5[CH2:22][C:19]([F:21])([F:20])[CH2:18]5)[cH:4][n:3]1.[F:30][B-](F)(F)F.F[B-](F)(F)F.F[N+]1(CC[N+]2(CCl)CC1)CC2>>[NH2:1][c:2]1[n:7][cH:6][c:5]([c:8]2[c:16]([c:12]3[n:11][c:10]([N:23]4[C@@H:28]([CH2:29][F:30])[CH2:27][O:26][CH2:25][CH2:24]4)[n:9]2)[CH2:15][CH2:14][N:13]3[CH:17]5[CH2:22][C:19]([F:21])([F:20])[CH2:18]5)[cH:4][n:3]1

Participants

5

Reactant 2

HCID 2724933SelectfluorHCID 118444360[(3S)-4-[4-(2-aminopyrimidin-5-yl)-7-(3,3-difluorocyclobutyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholin-3-yl]methanol

Product 1

HCID 178508376HCID 178508376, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-842cc26fe7ea4c29b0800ad0a3c063ff
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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