(Difluoromethyl)trimethylsilane → tert-butyl 6-(difluoromethyl)-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
Reaction equation
C[Si]([CH:1]([F:3])[F:2])(C)C.[CH3:4][C:5]([O:8][C:9]([N:11]1[CH2:28][c:27]([c:14]2[CH2:13][CH2:12]1)[c:18]([O:19][CH2:20][c:21]3[cH:26][cH:25][cH:24][cH:23][cH:22]3)[cH:17][c:16](Br)[cH:15]2)=[O:10])([CH3:7])[CH3:6]>>[CH3:4][C:5]([O:8][C:9]([N:11]1[CH2:28][c:27]([c:14]2[CH2:13][CH2:12]1)[c:18]([O:19][CH2:20][c:21]3[cH:26][cH:25][cH:24][cH:23][cH:22]3)[cH:17][c:16]([CH:1]([F:3])[F:2])[cH:15]2)=[O:10])([CH3:7])[CH3:6]Participants
8
Reactant 2
Product 1
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 80 °C
Sources & evidence
- ORD record
- ord-bccb5ac248864784850c9124aff43e64
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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