反应详情

温度

180 °C

To 25 mg of 4-(benzylamino)-6-chloropyridine-3-carboxyamide suspended in 0.2 mL of diphenylether, 18 mg of aniline and 9 mg of methanesulfonic acid were added and stirred at 180° C. for 30 minutes. After cooling, the reaction mixture was dissolved in chloroform, washed with saturated aqueous sodium bicarbonate, and dried on anhydrous sodium sulfate. The solvent was evaporated and the residue was purified by silica gel column chromatography (chloroform:methanol=40:1-10:1) to obtain 30 mg (99%) of the title compound as a slight yellow crystalline powder.

1. temperatureAfter cooling
2. washwashed with saturated aqueous sodium bicarbonate
3. dry with materialdried on anhydrous sodium sulfate
4. customThe solvent was evaporated
5. customthe residue was purified by silica gel column chromatography (chloroform:methanol=40:1-10:1)