Hydrochloric Acid → HCID 46174615, compound

HRID 2035664Notes

Reaction equation

HRID 2035664 reaction equation
[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:20][CH2:21][C:22]([C@@H:25]4[CH2:29][O:28]C(C)(C)[O:26]4)([CH3:24])[CH3:23])[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.Cl>CO>[N:1]1[N:2]=[C:3]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([O:20][CH2:21][C:22]([CH3:24])([CH3:23])[C@@H:25]([OH:26])[CH2:29][OH:28])[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67231245HCID 67231245, compound

Product 1

HCID 46174615HCID 46174615, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(R)-2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropoxy)quinoline (0.030 g, 0.072 mmol) was added to 1 N HCl in methanol and stirred for 30 minutes, then evaporated, co-evaporated once in methanol and triturated in DCM to isolate 23 mg of 95% pure desired product as a beige solid. MS ESI (+) m/z 379 (M+1) detected.

Workup

  1. customevaporated
  2. customtriturated in DCM

Sources & evidence

ORD record
ord-a0c23e2a0d5549e7b99de2dedbec117d
Source dataset
uspto-grants-2013_11
Patent number
US08575145B2

Reaction notes

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