反应详情

4-(Pyridine-3-yloxy)benzaldehyde (0.500 g, 2.510 mmol), 4-acetamidobenzene sulfonyl azide (0.724 g, 3.01 mmol), dimethyl (2-oxopropyl) phosphonate (0.412 mL, 3.01 mmol), and potassium carbonate (1.041 g, 7.53 mmol) in MeCN (10.5 mL) and MeOH (2.1 mL) was heated to 40° C. for 16 h while under N2. The solvent was removed and residue was redissolved in EtOAc and washed with water (3×) and brine (1×). The organic phase was separated, dried with Na2SO4 and evaporated to afford an oil. This material was chromatographed on silica (0-80% EtOAc in hexanes) to yield 0.238 g as an oil.

1. customThe solvent was removed
2. dissolutionresidue was redissolved in EtOAc
3. washwashed with water (3×) and brine (1×)
4. customThe organic phase was separated
5. dry with materialdried with Na2SO4
6. customevaporated
7. customto afford an oil
8. customThis material was chromatographed on silica (0-80% EtOAc in hexanes)
9. customto yield 0.238 g as an oil