HCID 66748429, compound → HCID 66747911, compound

HRID 2035887Notes

Reaction equation

HRID 2035887 reaction equation
[O:1]1[C:5]2[CH:6]=[C:7]([O:10][C:11]3[CH:16]=[CH:15][C:14]([C:17]4[C:22]5=[N:23][S:24](=[O:28])(=[O:27])[CH2:25][CH2:26][N:21]5[CH:20]=[CH:19][CH:18]=4)=[CH:13][CH:12]=3)[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1>C1COCC1.CO.[Pt](=O)=O>[O:1]1[C:5]2[CH:6]=[C:7]([O:10][C:11]3[CH:16]=[CH:15][C:14]([CH:17]4[C:22]5=[N:23][S:24](=[O:27])(=[O:28])[CH2:25][CH2:26][N:21]5[CH2:20][CH2:19][CH2:18]4)=[CH:13][CH:12]=3)[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1

Participants

5

Reactant 1

HCID 66748429HCID 66748429, compound

Product 1

HCID 66747911HCID 66747911, compoundYield 68.1%

Reagents, catalysts & solvents 3

HCID 345198Adams' catalystCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Platinum(IV) oxide (20 mg) was added to a solution of 9-[4-(2,3-dihydro-1-benzofuran-6-yloxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (100 mg) in THF (dry) (50 mL) and MeOH (50 mL). The mixture was stirred at room temperature under hydrogen for 3 hr. Activated carbon was added and the insoluble solid was removed by filtration through NH-silica gel/Celite pad (eluted with EtOAc). Platinum(IV) oxide (20 mg) was added and the mixture was stirred at room temperature under hydrogen overnight. Activated carbon was added and the insoluble solid was removed by filtration through NH-silica gel/Celite pad (eluted with EtOAc) and the filtrate was concentrated in vacuo. The residue was crystallized from THF/IPE to give the title compound (68.8 mg) as colorless crystals.

Workup

  1. additionActivated carbon was added
  2. customthe insoluble solid was removed by filtration through NH-silica gel/Celite pad (eluted with EtOAc)
  3. additionPlatinum(IV) oxide (20 mg) was added
  4. stirringthe mixture was stirred at room temperature under hydrogen overnight
  5. additionActivated carbon was added
  6. customthe insoluble solid was removed by filtration through NH-silica gel/Celite pad (eluted with EtOAc)
  7. concentrationthe filtrate was concentrated in vacuo
  8. customThe residue was crystallized from THF/IPE

Sources & evidence

ORD record
ord-3cba8bf260ca48a08eede05bc7ed0375
Source dataset
uspto-grants-2013_11
Patent number
US08575154B2

Reaction notes

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