HCID 66748670, compound → HCID 66748669, compound

HRID 2035933Notes

Reaction equation

HRID 2035933 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]3=[N:15][S:16](=[O:20])(=[O:19])[CH2:17][CH2:18][N:13]3[CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>CO.[Pt](=O)=O>[F:22][C:2]([F:1])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:14]3=[N:15][S:16](=[O:19])(=[O:20])[CH2:17][CH2:18][N:13]3[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 66748670HCID 66748670, compound

Product 1

HCID 66748669HCID 66748669, compoundYield 26.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

A mixture of 9-[4-(trifluoromethyl)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (250 mg) and platinum(IV) oxide (25.9 mg) in MeOH (10 mL) was stirred at room temperature under H2 for 20 hr. The reaction mixture was filtered by Celite and the filtrate was concentrated in vacuo. The residue was recrystallized from EtOAc-MeOH to give the title compound (68.0 mg) as a white solid.

Workup

  1. filtrationThe reaction mixture was filtered by Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was recrystallized from EtOAc-MeOH

Sources & evidence

ORD record
ord-e214c9279ed4459b9cb84940c86e6373
Source dataset
uspto-grants-2013_11
Patent number
US08575154B2

Reaction notes

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