Potassium Carbonate → 8-[6-(3-Methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-3-phenyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

HRID 2036077Notes

Reaction equation

HRID 2036077 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.[C:14]1([N:20]2[CH2:24][C:23]3([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[O:22][C:21]2=[O:30])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:27]3[CH2:26][CH2:25][C:23]4([O:22][C:21](=[O:30])[N:20]([C:14]5[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=5)[CH2:24]4)[CH2:29][CH2:28]3)=[CH:7][CH:6]=2)[S:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazineHCID 202864753-Phenyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one

Product 1

HCID 685550538-[6-(3-Methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-3-phenyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Procedure

The object product (72 mg, 29%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (130 mg), 3-phenyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one (142 mg) and potassium carbonate (127 mg).

Sources & evidence

ORD record
ord-2b4ba1ae98d14a319506ff22e20f1b5e
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

Loading…